What is Methylation?

Methylation can be defined as one of the ways to remove the toxins and some substances that may damage the metabolism. The homocysteine rises in the body by causing many diseases if the process is deranged in methylation paths and no sufficient methylation occurs. The methylation cycle must be maintained intact in order to maintain healthy

Methylation can also be defined as a biochemical process that takes place in DNA and some protein sequences where the genetic codes of living creatures are stored. All the body cells have the same genetic material, but the cells differentiate and perform different tasks with methylation, Methylation is an epigenetic mechanism that affects embryonic development before birth and development after birth under the influence of environmental factors. It also plays a role in the emergence of many diseases.

The genetic tests and tests called The Methylation Panel detect Methylation disorder, which is closely related to public health and diseases, The factors that cause gene mutation are researched, especially the MTHFR gene that plays a role in methylation disorder. The methylation cycle of people with the MTHFR gene mutation may be normal. In addition, it’s not enough just to do genetic tests. Functional methylation capacity must be also evaluated by doing a Methylation Panel Test along with genetic screening tests.

What Happens if The Methylation Cycle Breaks Down?

Natural balances in the neurological system and vessels are deranged with the increase of homocysteine load in the body. Cardiovascular diseases, various neurological diseases and the tendency to depression increase. “A brain fog”, described by forgetfulness, impaired concentration and confusion may occur. Genetic structuring is threatened, as the production of DNA and RNA in methylation will also be deranged. This means deranging the production of many hormones, enzymes and vital substances. Both lack and excess methylation are harmful to the body.

The main diseases that can occur as a result of derogation in the methylation cycle could be considered as psychiatric diseases as depression, bipolar disorder, schizophrenia, panic attacks,  histamine intolerance, allergic diseases, various cancers, immune system diseases, sleep disorders, type 2 diabetes, hormonal disorders, irregular periods, PCOS (Polycystic Ovary Syndrome), fertility problems, migraines, fatigue, Alzheimer’s, neurological diseases such as epilepsy, drug addiction and Autism spectrum.

In 30% of the population there is an irregularity in the methylation cycle. In people with slow methylation cycle; traits such as obsessive tendencies, lack of attention and concentration, ambitious and competitive personality structure, perfectionism, the height of libido, antisocial personality structure may ocur wheras in people with a high methylation cycle; hyperactivity, anxiety disorder, low libido, tendency to gain weight, low motivation, and paranoia may occur.

What is Methylation Analysis?

Amino acids such as methionine, cysteine; vitamins such as B6, B12, B9, B1, B2, C; minerals such as magnesium, selenium, zinc, cobalt, copper, and the presence of coenzyme Q10 are essential in a good methylation cycle. The methylation cycle is als deranged if the balances are deranged in any of them, Therefore, it is very important to analyze the levels of homocysteine, B12, folic acid, coenzyme Q10, selenium, zinc in the blood.

During the methylation analysis, SAM-e (S-Adenosyl Methionine, a methyl donor, which reduces the continuation of metabolic functions and structural damage), SAH (S-Adenosyl Homocysteine, i.e. methylation suppressor), the most powerful antioxidant that the body produces on the levels of glutathione GSSG (oxidized glutathione) and GSH (reduced glutathione) measurements can be made. Methyl support (methyl folate or methylcobalamin) may be required for the treatment of people with methylation disorders. In addition, personalized nutrition and supplements such as B12, B9 (folate), B6, B5 can be applied so that the body can best perform its biochemical processes. Thanks to this genetic test called the methylation panel, information about people regarding many physical and mental disorders can be obtained and individual-specific solutions for them can be provided to prevent and treat diseases before they ocur.

Why Does The Methylation Cycle Break Down?

Point mutations that occur in the MTHFR gene can be considered among the most common mutations in society. Changes in this gene may also play a role in deranging the methylation cycle. Vitamin B12 and folate are the two most important nutrients that are effective in the methylation cycle. Besides, they are required other vitamins, minerals and amino acids such as methionine, cysteine, taurine, DHA, zinc, magnesium, potassium, riboflavin, niacin, pyridoxine, betaine, choline and sulfur. Their inadequacy can derange the methylation cycle.

Nutritional errors and factors that derange digestion can also lead to a lack of nutrients that are important in the methylation cycle.

The invitation to insulin resistance and chronic inflammation is removed as a result of not getting enough healthy fats, proteins, excessive consumption of carbohydrates and simple sugars. This in turn leads to an increase in the need for methyl. Insulin is an anabolic hormone that allows not only glucose, but also minerals such as magnesium, potassium and amino acids to enter the cell. In order to maintain healthy methylation, these nutrients that act as coenzymes are needed in the cell. In insulin resistance, receptor insensitivity to these elements occurs and the hormone insulin cannot perform its normal functions. These nutrients, which must be present in the cell, cannot enter the cell due to the ineffectiveness of insulin, which deranges the methylation cycle.

B12 vitamin is also a must for a healthy methylation cycle. With B12 deficiency, the methylation cycle is deranged.

Digestive problems can derange vitamin and mineral absorption, leading to methyl deficiency. Acid deficiency in the stomach, the factors that derange the pancreatic and bile secretions, SIBO, and sensitivity to foods containing gluten, lecithin, casein, etc. derange digestive function. And this affects the absorption of vitamins and minerals. Their deficiency also leads to a derogation of the methylation cycle.

Some drugs can also derange or slow down the methylation cycle. In addition, there are studies showing that some dietary supplements used for weight loss also damage methylation by increasing the need for methyl.

Intestinal flora disorder can also directly affect methylation. Foods that contain preservatives and foods with flour and sugar lead to the deterioration of intestinal flora and intestinal permeability, stimulating the immune system in another way and can lead to chronic inflammation. Methylation balance can be restored when measures are taken to regulate intestinal flora in people with methylation problems.

Chronically high levels of histamine in the body may negatively affect too many body functions. Most of the foods contain a high level of histamine. Excessive consumption of these foods can also derange the methylation cycle by increasing methyl consumption. The enzyme Histamine N-Methyl Transferase (HNMT), which neutralizes histamine by breaking it down within the cell, is a methyl-dependent enzyme. Another enzyme that destroys histamine by breaking down is the DAO enzyme, most of which is found in the intestines. High histamine means high methyl consumption. Fermented products are in the first place in foods containing high histamine. Excessive consumption of such foods can lead to methyl deficiency by increasing methyl consumption due to the high histamine content. Aged bone broths, aged foods, deli products such as sausages, salami, sujuk and many foods and beverages such as wine, etc. increase methyl consumption.

Prolonged or chronic stress and anxiety also significantly increase the need for methyl. Since autoimmune diseases occur based on chronic inflammation, methyl consumption significantly increases in all of these diseases. Crohn’s disease, ulcerative colitis, Celiac, Hashimoto’s thyroiditis, Type 1 diabetes, Multiple Sclerosis, Rheumatoid Arthritis are also among them.

Alcohol and smoking also derange methylation by suppressing the enzyme methionine synthase (MS). In addition, glutathione reserves, one of the most valuable antioxidants for the body, also rapidly depletes.

Apart from all these, environmental toxins, a sedentary lifestyle, chronic infections are also conditions that threaten the methylation cycle.

How to Fix Methylation?

The use of  uncontrolled of drugs containing methyl groups can derange health. Detecting a mutation in any gene involved in methylation does not necessarily mean that a person needs methyl. A person may also have an excess amount of methyl. However, keep methylation in balance is the ideal one that can only be achieved with a holistic approach with systematic analysis and follow-up under the supervision of experts.


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